The beta-1 and beta-2 adrenoceptor occupancies were proved to be the most appropriate indicators for cardiac and pulmonary adverse reactions evoked by ophthalmic beta-blocking agents. Nasolacrimal occlusion was estimated to decrease the exercise pulse rate and FEV1 by 65% and 50%, respectively. results in a better entrance of adrenergic anti-glaucomatous compounds within the eye. Concave relationships were obtained between a decrease in exercise pulse rate and the beta-1 receptor occupancy and between a decrease in FEV1 and beta-2 receptor occupancy, respectively. Molecular Docking and Drug Discovery in -Adrenergic Receptors. timolol ophthalmic (eye) TIMOLOL SOLUTION - OPHTHALMIC (TIE-moh-lohl) COMMON BRAND NAME(S): Timoptic. ![]() The maximum occupancies for beta-1 and beta-2 receptors after ordinary ophthalmic administration were 52% and 88% for carteolol, 52% and 61% for befunolol, 62% and 82% for timolol, and 44% and 3% for betaxolol, respectively. The beta-1 and beta-2 receptor occupancies after ophthalmic administration were calculated to be quite high as well as those after oral administration. Beta blockers antagonize b1 and b2 receptors in the ciliary body's. This essentially blocks the normal beta adrenergic response. The relationship between the occupancies for beta-1 and beta-2 adrenoceptors and the effects on the exercise pulse rate or the forced expiratory volume in one second (FEV1) after topical administration of carteolol, befunolol, timolol and betaxolol was analyzed using a ternary complex model. 24.2 The 242 SITA-Standard pattern deviation of the right eye of the woman shown in. These drugs that attach to the beta 1 adrenergic receptor site and block the norepinephrine from attaching to the receptor site. ![]() To assess quantitatively the risks of ophthalmic beta-blocking agents for cardiovascular and respiratory adverse reactions, we analyzed the binding kinetics of beta-blocking agents to the beta-1 and beta-2 adrenoceptors.
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